Tuesday, November 4th
08:00 – 09:30
Participant Registration & Check In
09:30 – 10:00
Welcome coffee
10:00 – 11:30
Formal opening & welcome address
11:35 - 12:50
Inaugural Lecture
"The Brucella genomic origami: How bacteria without plasmids or external recombination evolve and adapt to their intracellular niche"
Dr. Edgardo Moreno
"The Brucella genomic origami: How bacteria without plasmids or external recombination evolve and adapt to their intracellular niche"
Dr. Edgardo Moreno
12:50 – 14:00
Lunch
Topic 1 Evolution & Taxonomy
Session moderator – Edgardo Moreno
Session moderator – Edgardo Moreno
14:00-15:05
Keynote lecture
"Brucella phylogeography across Italy, the Mediterranean, and Europe"
Giuliano Garofolo
"Brucella phylogeography across Italy, the Mediterranean, and Europe"
Giuliano Garofolo
15:05-16:00
First Lecture Session:
"Genomic analysis of Brucella ovis strains reveals unique Italian diversity within a global context"
Katiuscia Zilli
"Brucella intergenic-OME: Genomic characterization of intergenic regions unveiling structural similarities and differences within chromosomes and Brucella species"
Carlos Chacón Díaz
"Prediction of genetic traits linked to phenotypic diversification of Brucella using large-scale sequencing"
Dirk Hofreuter
"Genomic analysis of Brucella ovis strains reveals unique Italian diversity within a global context"
Katiuscia Zilli
"Brucella intergenic-OME: Genomic characterization of intergenic regions unveiling structural similarities and differences within chromosomes and Brucella species"
Carlos Chacón Díaz
"Prediction of genetic traits linked to phenotypic diversification of Brucella using large-scale sequencing"
Dirk Hofreuter
16:00-17:00
Coffee Break
17:00-18:00
Second lecture session
"Phylogeographic insights into Brucella abortus circulating in Latin America"
Caterina Guzmán Verri
"Phylogeography and cross-border movement of Brucella"
Jeffrey Foster
"Discovery of a new specific bacteriophage for Brucella canis"
Ayfer GÜLLÜ YÜCETEPE
"Phylogeographic insights into Brucella abortus circulating in Latin America"
Caterina Guzmán Verri
"Phylogeography and cross-border movement of Brucella"
Jeffrey Foster
"Discovery of a new specific bacteriophage for Brucella canis"
Ayfer GÜLLÜ YÜCETEPE
18:00
Closing of the day
Wednesday, November 5
Topic 2 Wildlife & New Hosts
Session moderator – Anne Keriel
Session moderator – Anne Keriel
08:00-09:05
Keynote lecture
"The Road to One Health"
Dr. Andrew Cunningham
"The Road to One Health"
Dr. Andrew Cunningham
09:05-10:00
First Lecture Session
"After 20 years of neurobrucellosis in striped dolphins: what we learned"
Gabriela Hernández
"Outbreak of Brucella melitensis in goitered gazelle (Gazella subgutturosa) on a Turkish farm"
Sevil Erdenliğ Gürbİlek
"Comprehensive epidemiological baseline for Brucella spp. in South African wild mammals with molecular differentiation of B. abortus & B. melitensis"
Carlo Andrea Cossu
"After 20 years of neurobrucellosis in striped dolphins: what we learned"
Gabriela Hernández
"Outbreak of Brucella melitensis in goitered gazelle (Gazella subgutturosa) on a Turkish farm"
Sevil Erdenliğ Gürbİlek
"Comprehensive epidemiological baseline for Brucella spp. in South African wild mammals with molecular differentiation of B. abortus & B. melitensis"
Carlo Andrea Cossu
10:00-11:05
Coffee Break
11:05-12:00
Second lecture session
"First evidence of Brucella- like isolates in neotropical bats from in the Brazilian Cerrado"
Amanda Carvalho Rosado Ferreira
"First identification and isolation of Brucella microti in french sheep and goat flocks"
Vitomir Djokic
"Serological detection of Brucella sp. in opossums (Didelphis virginiana) in an urban setting in Mexico"
Gabriela Romina Hernández Carbajal
"First evidence of Brucella- like isolates in neotropical bats from in the Brazilian Cerrado"
Amanda Carvalho Rosado Ferreira
"First identification and isolation of Brucella microti in french sheep and goat flocks"
Vitomir Djokic
"Serological detection of Brucella sp. in opossums (Didelphis virginiana) in an urban setting in Mexico"
Gabriela Romina Hernández Carbajal
12:00 – 13:10
Lunch
Topic 3 Epidemiology
Session moderator – Gabriela Hernández
Session moderator – Gabriela Hernández
13:10-14:10
Keynote lecture
"Always‑on web tools for genomic epidemiology: from Pathogenwatch to amr.watch"
Dr. Julio Díaz Caballero
"Always‑on web tools for genomic epidemiology: from Pathogenwatch to amr.watch"
Dr. Julio Díaz Caballero
14:10-15:10
First lecture session
"Towards the eradication of brucellosis in Italy: Epidemiological insights and strategic perspectives"
Fabrizio De Massis
"Transmission model of bovine brucellosis in Minas Gerais, Brazil"
Elaine Dorneles
"Investigations on infections caused by new Brucella species in neotropical forests"
Anne Keriel
"Towards the eradication of brucellosis in Italy: Epidemiological insights and strategic perspectives"
Fabrizio De Massis
"Transmission model of bovine brucellosis in Minas Gerais, Brazil"
Elaine Dorneles
"Investigations on infections caused by new Brucella species in neotropical forests"
Anne Keriel
15:10-16:10
Coffee Break & Poster Session
16:10-17:30
Second Lecture Session
"Molecular and serological detection and characterization of Brucella species in Tanzanian livestock"
Roland Ashford
"Determination and characterization of (Novel) circulating strains of Brucella sp. within the national bovine brucellosis control program in Ecuador"
Ana Garrido Haro
"Identification of Brucella spp. in compost-bedded pack barns and dairy cows during the transition period housed in this system"
Maysa Serpa Gonçalves
"Towards the validation of a RT-PCR assay for the detection of Brucella DNA in different types of animal samples"
Sonia Vection
"Molecular and serological detection and characterization of Brucella species in Tanzanian livestock"
Roland Ashford
"Determination and characterization of (Novel) circulating strains of Brucella sp. within the national bovine brucellosis control program in Ecuador"
Ana Garrido Haro
"Identification of Brucella spp. in compost-bedded pack barns and dairy cows during the transition period housed in this system"
Maysa Serpa Gonçalves
"Towards the validation of a RT-PCR assay for the detection of Brucella DNA in different types of animal samples"
Sonia Vection
17:30
Closing Of the Day
Thursday, November 6
Topic 4 Diagnosis & Treatment
Session moderator – Angela Arenas
Session moderator – Angela Arenas
08:00-09:05
Keynote lecture
"Human Brucellosis: Clinical challenges of a neglected zoonotic infection"
Dr. Jorge Wallach
"Human Brucellosis: Clinical challenges of a neglected zoonotic infection"
Dr. Jorge Wallach
09:05-10:00
First lecture session
"Canine brucellosis: treatment and challenges"
Fabrizio De Massis
"Intracellular heterogeneity contributes to antibiotic treatment survival"
Maren Ketterer
"Brucellosis in South Africa: challenges in diagnosis, transmission, and control"
Henriette van Heerden
"Canine brucellosis: treatment and challenges"
Fabrizio De Massis
"Intracellular heterogeneity contributes to antibiotic treatment survival"
Maren Ketterer
"Brucellosis in South Africa: challenges in diagnosis, transmission, and control"
Henriette van Heerden
10:00-11:05
Coffee Break & Poster Session
11:05-12:20
Second lecture session
"Development of an ex vivo IFN-γ assay for porcine brucellosis diagnosis"
David Fretin
"Recapitulating therapeutic failure in human brucellosis: A PBMC-based model for intracellular Brucella melitensis"
Christoph Dehio
"Development and application of precise diagnosis technology for animal brucellosis"
Jiabo Ding
"Brucellin Aquilon: prueba diagnóstica de Brucella en cerdos"
Carlos Chipana (Zendal)
"Development of an ex vivo IFN-γ assay for porcine brucellosis diagnosis"
David Fretin
"Recapitulating therapeutic failure in human brucellosis: A PBMC-based model for intracellular Brucella melitensis"
Christoph Dehio
"Development and application of precise diagnosis technology for animal brucellosis"
Jiabo Ding
"Brucellin Aquilon: prueba diagnóstica de Brucella en cerdos"
Carlos Chipana (Zendal)
12:20 – 13:45
Lunch
Topic 5 Immunology & Pathogenesis
Session moderator – Elías Barquero
Session moderator – Elías Barquero
13:45 - 14:45
Keynote Lecture
"Silence is golden – how MucR’s repressor activity contributes to Brucella virulence"
Dr. Marty Roop
"Silence is golden – how MucR’s repressor activity contributes to Brucella virulence"
Dr. Marty Roop
14:45 - 15:45
First Lecture Session
"Brucella Nyx effectors impact key cellular proteins involved in reproductive tissue integrity"
Suzana Salcedo
"CRISPR-Cas9 screens in macrophages identify host genes required for early stages of intracellular Brucella and Mycobacterium infection"
Sean Crosson
"A new model of Brucella-induced spondyloarthritis"
Judith Smith
"Brucella Nyx effectors impact key cellular proteins involved in reproductive tissue integrity"
Suzana Salcedo
"CRISPR-Cas9 screens in macrophages identify host genes required for early stages of intracellular Brucella and Mycobacterium infection"
Sean Crosson
"A new model of Brucella-induced spondyloarthritis"
Judith Smith
15:45 - 16:45
Coffee Break & Poster Session
16:45 - 17:45
Second Lecture Session
"MdrA and VjbR antagonize MucR repression of the gene encoding the autotransporter adhesin btaE"
Connor Cribb
"Role of caspase-1 and caspase-11 in the pathogenesis of Brucella ovis in the murine materno-fetal model"
Renato de Lima Santos
"Unraveling the role of a putative exopolysaccharide in Brucella virulence"
Jodi Ogle
"MdrA and VjbR antagonize MucR repression of the gene encoding the autotransporter adhesin btaE"
Connor Cribb
"Role of caspase-1 and caspase-11 in the pathogenesis of Brucella ovis in the murine materno-fetal model"
Renato de Lima Santos
"Unraveling the role of a putative exopolysaccharide in Brucella virulence"
Jodi Ogle
17:45
Closing of the day
Friday, November 7
Topic 6 Vaccines
Session moderator – Caterina Guzmán-Verri
Session moderator – Caterina Guzmán-Verri
08:00-09:05
Keynote lecture
"An overview of latest research on brucellosis vaccine: can we enhance protection efficacy with trained immunity?"
Dr. Sergio Oliveira
"An overview of latest research on brucellosis vaccine: can we enhance protection efficacy with trained immunity?"
Dr. Sergio Oliveira
09:05-10:00
First lecture session
"Assessment of long-term efficacy of Brucella abortus RB51 vaccine by challenge of pregnant water buffaloes vaccinated at 6-9 months age"
Flavio Sacchini
"Ineffectiveness of the RB51 vaccine against bovine brucellosis in Iran"
Maryam Dadar
"Recognition of Brucella mutant stimulates robust antimicrobial response"
David Pascual
"Assessment of long-term efficacy of Brucella abortus RB51 vaccine by challenge of pregnant water buffaloes vaccinated at 6-9 months age"
Flavio Sacchini
"Ineffectiveness of the RB51 vaccine against bovine brucellosis in Iran"
Maryam Dadar
"Recognition of Brucella mutant stimulates robust antimicrobial response"
David Pascual
10:00-11:05
Coffee Break
11:05-12:00
Second Lecture Session
"Enhanced Brucella vaccine annotations from PubMed using large language models and bioinformatics analysis"
Jie Zheng
"An iterative glycoengineering platform towards custom-made recombinant Brucella O-antigen glycans for diagnostics and vaccines"
Ian Passmore
"Viable count and safety assessment of a reduced dose of the Brucella abortus S19 vaccine"
Faranani Ramagoma
"Enhanced Brucella vaccine annotations from PubMed using large language models and bioinformatics analysis"
Jie Zheng
"An iterative glycoengineering platform towards custom-made recombinant Brucella O-antigen glycans for diagnostics and vaccines"
Ian Passmore
"Viable count and safety assessment of a reduced dose of the Brucella abortus S19 vaccine"
Faranani Ramagoma
12:00 – 13:10
Lunch
Topic 7 Molecular & Cellular Microbiology
Session moderator – Xavier De Bolle
Session moderator – Xavier De Bolle
13:10-14:10
Keynote lecture
"Conserved growth and survival mechanisms in Hyphomicrobiales"
Dr. Anke Becker
"Conserved growth and survival mechanisms in Hyphomicrobiales"
Dr. Anke Becker
14:10-15:30
First Lecture Session
"Defining the regulatory mechanism between the small RNA, MavR and murF mRNA in Brucella"
Jillian Marshall
"Assessing the contributions of Brucella abortus genes to fitness during bovine infection"
Aretha Fiebig
"Breaking the silence—role of MucR as a virulence determinant in Brucella"
Ian Barton
"Molecular insights into Brucella abortus VirJ function in effector translocation by the Type IV secretion system"
Laurent Terradot
"Defining the regulatory mechanism between the small RNA, MavR and murF mRNA in Brucella"
Jillian Marshall
"Assessing the contributions of Brucella abortus genes to fitness during bovine infection"
Aretha Fiebig
"Breaking the silence—role of MucR as a virulence determinant in Brucella"
Ian Barton
"Molecular insights into Brucella abortus VirJ function in effector translocation by the Type IV secretion system"
Laurent Terradot
15:30-16:30
Coffee Break & Poster session
16:30-17:30
Second Lecture Session
"The quorum-sensing regulators VjbR and BabR interact with MucR to regulate transcription of the Brucella Type IV secretion system genes"
Graham Bitzer
"A conserved DUF protein links glycoconjugate modification to cell envelope stability in Brucella"
Melene Alakavuklar
"Spatial constraints for the lipopolysaccharide biogenesis in Brucella abortus"
Audrey Verhaeghe
"The quorum-sensing regulators VjbR and BabR interact with MucR to regulate transcription of the Brucella Type IV secretion system genes"
Graham Bitzer
"A conserved DUF protein links glycoconjugate modification to cell envelope stability in Brucella"
Melene Alakavuklar
"Spatial constraints for the lipopolysaccharide biogenesis in Brucella abortus"
Audrey Verhaeghe
17:30-17:45
Conference Closing Ceremony
Caterina Guzmán-Verri
Caterina Guzmán-Verri
17:45-18:00
International Brucellosis Society Meeting: Organization of the next meeting in the US
19:00
Social event: closing dinner